Language
• #### Related Blog

• Unable to find any related blog!

Effective dose is a dose quantity in the International Commission on Radiological Protection (ICRP) system of radiological protection.[1]

It is the tissue-weighted sum of the equivalent doses in all specified tissues and organs of the human body and represents the stochastic health risk to the whole body, which is the probability of cancer induction and genetic effects, of low levels of ionising radiation.[2][3] It takes into account the type of radiation and the nature of each organ or tissue being irradiated, and enables summation of organ doses due to varying levels and types of radiation, both internal and external, to produce an overall calculated effective dose.

The SI unit for effective dose is the sievert (Sv) which represents a 5.5% chance of developing cancer.[4] The effective dose is not intended as a measure of deterministic health effects, which is the severity of acute tissue damage that is certain to happen, that is measured by the quantity absorbed dose.[5]

The concept of effective dose was developed by Wolfgang Jacobi and published in 1975, and was so convincing that the ICRP incorporated it into their 1977 general recommendations (publication 26) as "effective dose equivalent".[6] The name "effective dose" replaced the name "effective dose equivalent" in 1991.[7] Since 1977 it has been the central quantity for dose limitation in the ICRP international system of radiological protection.[8]

## Uses

External dose quantities used in radiation protection and dosimetry

According to the ICRP, the main uses of effective dose are the prospective dose assessment for planning and optimisation in radiological protection, and demonstration of compliance with dose limits for regulatory purposes. The effective dose is thus a central dose quantity for regulatory purposes.[9]

The ICRP also says that effective dose has made a significant contribution to radiological protection as it has enabled doses to be summed from whole and partial body exposure from external radiation of various types and from intakes of radionuclides.[10]

### Usage for external dose

The calculation of effective dose is required for partial or non-uniform irradiation of the human body because equivalent dose does not consider the tissue irradiated, but only the radiation type. Various body tissues react to ionising radiation in different ways, so the ICRP has assigned sensitivity factors to specified tissues and organs so that the effect of partial irradiation can be calculated if the irradiated regions are known.[11] A radiation field irradiating only a portion of the body will carry lower risk than if the same field irradiated the whole body. To take this into account, the effective doses to the component parts of the body which have been irradiated are calculated and summed. This becomes the effective dose for the whole body, dose quantity E. It is a "protection" dose quantity which can be calculated, but cannot be measured in practice.

An effective dose will carry the same effective risk to the whole body regardless of where it was applied, and it will carry the same effective risk as the same amount of equivalent dose applied uniformly to the whole body.

### Usage for internal dose

Effective dose can be calculated for committed dose which is the internal dose resulting from inhaling, ingesting, or injecting radioactive materials.

The dose quantity used is:

Committed effective dose, E(t) is the sum of the products of the committed organ or tissue equivalent doses and the appropriate tissue weighting factors WT, where t is the integration time in years following the intake. The commitment period is taken to be 50 years for adults, and to age 70 years for children.[12]

## Calculation of effective dose

Graphic showing relationships of protection dose quantities in SI units

Ionizing radiation deposits energy in the matter being irradiated. The quantity used to express this is the absorbed dose, a physical dose quantity that is dependent on the level of incident radiation and the absorption properties of the irradiated object. Absorbed dose is a physical quantity, and is not a satisfactory indicator of biological effect, so to allow consideration of the stochastic radiological risk, the dose quantities equivalent dose and effective dose were devised by the International Commission on Radiation Units and Measurements (ICRU) and the ICRP to calculate the biological effect of an absorbed dose.

To obtain an effective dose, the calculated absorbed organ dose DT is first corrected for the radiation type using factor WR to give a weighted average of the equivalent dose quantity HT received in irradiated body tissues, and the result is further corrected for the tissues or organs being irradiated using factor WT, to produce the effective dose quantity E.

The sum of effective doses to all organs and tissues of the body represents the effective dose for the whole body. If only part of the body is irradiated, then only those regions are used to calculate the effective dose. The tissue weighting factors summate to 1.0, so that if an entire body is radiated with uniformly penetrating external radiation, the effective dose for the entire body is equal to the equivalent dose for the entire body.

### Use of tissue weighting factor WT

The ICRP tissue weighting factors are given in the accompanying table, and the equations used to calculate from either absorbed dose or equivalent dose are also given.

Some tissues like bone marrow are particularly sensitive to radiation, so they are given a weighting factor that is disproportionally large relative to the fraction of body mass they represent. Other tissues like the hard bone surface are particularly insensitive to radiation and are assigned a disproportionally low weighting factor.

Weighting factors for different tissues[13]
Organs Tissue weighting factors
ICRP26
1977
ICRP60
1990[14]
ICRP103
2007[15]
Red Bone Marrow 0.12 0.12 0.13
Colon - 0.12 0.19
Lung 0.12 0.12 0.16
Stomach - 0.12 0.12
Breasts 0.15 0.05 0.12
Liver - 0.05 0.04
Oesophagus - 0.05 0.04
Thyroid 0.03 0.05 0.04
Skin - 0.01 0.01
Bone surface 0.03 0.01 0.01
Salivary glands - - 0.01
Brain - - 0.01
Remainder of body 0.30 0.05 0.12
Total 1.00 1.00 1.00

Calculating from the equivalent dose:

${\displaystyle E=\sum _{T}W_{T}\cdot H_{T}=\sum _{T}W_{T}\sum _{R}W_{R}\cdot {\bar {D}}_{T,R}}$.

Calculating from the absorbed dose:

${\displaystyle E=\sum _{T}W_{T}\sum _{R}W_{R}\cdot {\frac {\int _{T}D_{R}(x,y,z)\rho (x,y,z)dV}{\int _{T}\rho (x,y,z)dV}}}$

Where

${\displaystyle E}$ is the effective dose to the entire organism
${\displaystyle H_{T}}$ is the equivalent dose absorbed by tissue T
${\displaystyle W_{T}}$ is the tissue weighting factor defined by regulation
${\displaystyle W_{R}}$ is the radiation weighting factor defined by regulation
${\displaystyle {\bar {D}}_{T,R}}$ is the mass-averaged absorbed dose in tissue T by radiation type R
${\displaystyle D_{R}(x,y,z)}$ is the absorbed dose from radiation type R as a function of location
${\displaystyle \rho (x,y,z)}$ is the density as a function of location
${\displaystyle V}$ is volume
${\displaystyle T}$ is the tissue or organ of interest

The ICRP tissue weighting factors are chosen to represent the fraction of health risk, or biological effect, which is attributable to the specific tissue named. These weighting factors have been revised twice, as shown in the chart above.

The US Nuclear Regulatory Commission still endorses the ICRP's 1977 tissue weighting factors in their regulations, in spite of the ICRP's later revised recommendations.[16]

## By medical imaging type

Effective dose by medical imaging type
Target organs Exam type Effective dose in adults[17] Equivalent time of background radiation[17]
Abdominal CT of abdomen and pelvis 10 mSv 3 years
CT of abdomen and pelvis, with + without radiocontrast 20 mSv 7 years
CT Colonography 6 mSv 2 years
Intravenous pyelogram 3 mSv 1 year
Upper gastrointestinal series 6 mSv 2 years
Lower gastrointestinal series 8 mSv 3 years
Bones Spine X-ray 1.5 mSv 6 months
X-ray of extremity 0.001 mSv 3 hours
Central nervous system CT of the head 2 mSv 8 months
CT of the head, with + without radiocontrast 4 mSv 16 months
CT of the spine 6 mSv 2 years
Chest CT of the chest 7 mSv 2 years
CT of the chest, lung cancer screening protocol 1.5 mSv 6 months
Chest X-ray 0.1 mSv 10 days
Dental X-ray 0.005 mSv 1 day
Heart Coronary CT angiography 12 mSv 4 years
Coronary CT calcium scan 3 mSv 1 year
DEXA (bone density) 0.001 mSv 3 hours
PET-CT combination 25 mSv 8 years
Mammography 0.4 mSv 7 weeks

## Health effects

Ionizing radiation is generally harmful and potentially lethal to living things but can have health benefits in radiation therapy for the treatment of cancer and thyrotoxicosis. Its most common impact is the induction of cancer with a latent period of years or decades after exposure. High doses can cause visually dramatic radiation burns, and/or rapid fatality through acute radiation syndrome. Controlled doses are used for medical imaging and radiotherapy.

## Regulatory nomenclature

### UK regulations

The UK Ionising Radiations Regulations 1999 defines its usage of the term effective dose; "Any reference to an effective dose means the sum of the effective dose to the whole body from external radiation and the committed effective dose from internal radiation."[18]

### US effective dose equivalent

The US Nuclear Regulatory Commission has retained in the US regulation system the older term effective dose equivalent to refer to a similar quantity to the ICRP effective dose. The NRC's total effective dose equivalent (TEDE) is the sum of external effective dose with internal committed dose; in other words all sources of dose.

In the US, cumulative equivalent dose due to external whole-body exposure is normally reported to nuclear energy workers in regular dosimetry reports.

• deep-dose equivalent, (DDE) which is properly a whole-body equivalent dose
• shallow dose equivalent, (SDE) which is actually the effective dose to the skin

## History

The concept of effective dose was introduced in 1975 by Wolfgang Jacobi (1928–2015) in his publication "The concept of an effective dose: a proposal for the combination of organ doses".[6][19] It was quickly included in 1977 as “effective dose equivalent” into Publication 26 by the ICRP. In 1991, ICRP publication 60 shortened the name to "effective dose."[20] This quantity is sometimes incorrectly referred to as the "dose equivalent" because of the earlier name, and that misnomer in turn causes confusion with equivalent dose. The tissue weighting factors were revised in 1990 and 2007 due to new data.

## Future use of Effective Dose

At the ICRP 3rd International Symposium on the System of Radiological Protection in October 2015, ICRP Task Group 79 reported on the "Use of Effective Dose as a Risk-related Radiological Protection Quantity".

This included a proposal to discontinue use of equivalent dose as a separate protection quantity. This would avoid confusion between equivalent dose, effective dose and dose equivalent, and to use absorbed dose in Gy as a more appropriate quantity for limiting deterministic effects to the eye lens, skin, hands & feet.[21]

It was also proposed that effective dose could be used as a rough indicator of possible risk from medical examinations. These proposals will need to go through the following stages:

• Discussion within ICRP Committees
• Revision of report by Task Group
• Reconsideration by Committees and Main Commission
• Public Consultation

## References

1. ^ ICRP publication, 103 para 103
2. ^ ICRP publication 103, glossary
3. ^ ICRP publication 103, para 104 and 105
4. ^ ICRP publication 103
5. ^ ICRP report 103 para 104 and 105
6. ^ a b Journal of Radiological protection Vol.35 No.3 2015. "Obituary - Wolfgang Jacobi 1928 - 2015."
7. ^ ICRP publication 103 executive summary para 101
8. ^ ICRP publication, 103 para 103
9. ^ ICRP publication 103 executive summary para j
10. ^ ICRP publication 103 para 101
11. ^ ICRP publication 103, para 22 & glossary
12. ^ ICRP publication 103 - Glossary.
13. ^ UNSCEAR-2008 Annex A page 40, table A1, retrieved 2011-7-20
14. ^ "1990 Recommendations of the International Commission on Radiological Protection". Annals of the ICRP. ICRP publication 60. 21 (1-3). 1991. ISBN 978-0-08-041144-6. Retrieved 17 May 2012.
15. ^ "The 2007 Recommendations of the International Commission on Radiological Protection". Annals of the ICRP. ICRP publication 103. 37 (2-4). 2007. ISBN 978-0-7020-3048-2. Archived from the original on 16 November 2012. Retrieved 17 May 2012.
16. ^ 10 CFR 20.1003. US Nuclear Regulatory Commission. 2009. Retrieved 25 November 2012.
17. ^ a b "Radiation Dose in X-Ray and CT Exams". RadiologyInfo.org by Radiological Society of North America. Retrieved 2017-10-23.
18. ^ The UK Ionising Radiations Regulations 1999
19. ^ Jacobi W (1975). "The concept of effective dose - A proposal for the combination of organ doses". Radiat. Environ. Biophys (12): 101–109.
20. ^ ICRP publication 103 paragraph 101
21. ^ "Use of Effective Dose", John Harrison. 3rd International Symposium on the System of Radiological Protection, October 2015, Seoul.