Cell Therapy

For the last few decades scientist have been researching the involvement of the immune system in cancer development to discover potential cure. Immune cells has been known to play an important role in regulating tumor progression, thus stimulating immune reactions towards tumors can be an attractive therapeutic targeting cancer. More and more clinical data has been shown positive signs of immunotherapy and cell therapy as potential cure for cancer.

CAR T Cells Therapy

After the success of PD-1/PDL-1 inhibitors on the market, many researchers are turning their attention to CAR-T therapy, which treated leukemia and lymphoma successfully.

In a CAR-T therapy, T cells from a patient was extracted and then genetically modified to express a Chimeric Antigen Receptor (CAR) on their cell membrane and expanded in vitro. This receptor consists of an external target-binding domain designed to recognize a specific tumor antigen and an internal activation domain responsible for activating the T cell when the CAR-T binds its target. Finally, these T cells are reinfused into the patient to kill the cancer cells.

Immunotherapies using checkpoint inhibitors such as of PD-1/PDL-1 inhibitors have already been proven successful in clinical trials. They block a mechanism that tumor cells use to hide from immune system. CAR-T cells therapy goes one step further by engineering the T cells themselves to enhance the response from the immune system against tumor cells.

This article duplicated from: Cell Therapy

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